Study of the Lipophilicity of Potential Antituberculotic Compounds by Reversed-Phase Thin-Layer Chromatography

Reversed-phase (RP) TLC retention behavior has been examined for two series of potential antituberculotic drugs. Effects of the type and proportion of the organic component of the mobile phase were tested, because these can affect retention. Experimentally measured lipophilicity values and values calculated by means of a computational method were compared to determine the extent of any correlation. It was found that substitution of the aromatic ring, in particular with chlorofluoro or more complicated substituents, negatively affected the correlation between measured and calculated values.