Synthesis and anti-HIV evaluation of new 2-Thioxoimidazolidin-4-ones and their Arylidine (styryl) derivatives

1,3-Bis{(2-thiophene-2-yl)ethyl}-5-(arylidine)-2-thioxoimidazolidin-4-ones (5a – 5 m) have been synthesized by condensation of 1,3-diarylalkyl-2-thiohydantoin (4) with various aromatic aldehydes. Compound (4) was prepared by the reaction of 1,3-bis (2-thien-2-yl-ethyl)-thiourea (3) with chloroacetic acid. The synthesized compounds have been tested for their anti-HIV-1 and -2 effects, but did not show any specific anti-HIV activity. The structures of newly synthesized compounds were established on the basis of elemental analyses, 1 H NMR, IR and mass spectrometry data.