Synthesis and anti-HIV evaluation of new 2-Thioxoimidazolidin-4-ones and their Arylidine (styryl) derivatives

被引：0

作者：

D. H. Mahajan

K. H. Chikhalia

C. Pannecouque

E. De Clercq

机构：

[1] Uka Tarsadia University,Department of Chemistry (CGBIBT)

[2] Gujarat University,Department of Chemistry

[3] Rega Institute for Medical Research,undefined

来源：

Pharmaceutical Chemistry Journal | 2012年 / 46卷

关键词：

2-thioxoimidazolidin-4-one; 2-thiohydantoin; arylidine; styryl; anti-HIV; HIV-1; HIV-2;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

1,3-Bis{(2-thiophene-2-yl)ethyl}-5-(arylidine)-2-thioxoimidazolidin-4-ones (5a – 5 m) have been synthesized by condensation of 1,3-diarylalkyl-2-thiohydantoin (4) with various aromatic aldehydes. Compound (4) was prepared by the reaction of 1,3-bis (2-thien-2-yl-ethyl)-thiourea (3) with chloroacetic acid. The synthesized compounds have been tested for their anti-HIV-1 and -2 effects, but did not show any specific anti-HIV activity. The structures of newly synthesized compounds were established on the basis of elemental analyses, 1 H NMR, IR and mass spectrometry data.

引用

页码：165 / 170

页数：5

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