Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors

被引：0
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作者：
L. Parnetti
S. Amici
A. Lanari
C. Romani
C. Antognelli
N. Andreasen
L. Minthon
P. Davidsson
H. Pottel
K. Blennow
V. Gallai
机构：
[1] Department of Neuroscience,
[2] Perugia University,undefined
[3] Perugia,undefined
[4] Italy,undefined
[5] Department of Genetics and Molecular Biology,undefined
[6] Perugia University,undefined
[7] Perugia,undefined
[8] Italy,undefined
[9] Department of Rehabilitation,undefined
[10] Piteå,undefined
[11] Sweden,undefined
[12] Department of Psychiatry,undefined
[13] Mälmo University Hospital,undefined
[14] Mälmo,undefined
[15] Sweden,undefined
[16] Department of Neurochemistry,undefined
[17] Göteborg University,undefined
[18] Göteborg,undefined
[19] Sweden,undefined
[20] Innogenetics,undefined
[21] Ghent,undefined
[22] Belgium,undefined
来源：
Neurological Sciences | 2002年 / 23卷
关键词：
Placebo; Cerebrospinal Fluid; Acetylcholinesterase; Untreated Patient; Moderate Degree;
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摘要：
In order to evaluate the biochemical effects of long-term treatment with inhibitors of acetylcholinesterase (AChE) in patients with Alzheimer's disease (AD), we measured the activities of AChE and butyrylcholinesterase (BuChe) and the concentrations of β-amyloid (1–42), τ and phosphorylated τ proteins in the cerebrospinal fluid (CSF). A total of 91 patients suffering from probable AD of mild to moderate degree were treated for 6 months with donepezil (n=59), galantamine (n=15), rivastigmine (n=10), or placebo (n=7). AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Untreated patients did not show any AChE activity variation. BuChE did not show any change in any of the groups studied. Mean values of β-amyloid(1–42), total τ and phosphorylated τ also did not vary significantly. We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment.
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页码：s95 / s96
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