Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

被引：0

作者：

Daniel L. McCartney

Josine L. Min

Rebecca C. Richmond

Ake T. Lu

Maria K. Sobczyk

Gail Davies

Linda Broer

Xiuqing Guo

Ayoung Jeong

Jeesun Jung

Silva Kasela

Seyma Katrinli

Pei-Lun Kuo

Pamela R. Matias-Garcia

Pashupati P. Mishra

Marianne Nygaard

Teemu Palviainen

Amit Patki

Laura M. Raffield

Scott M. Ratliff

Tom G. Richardson

Oliver Robinson

Mette Soerensen

Dianjianyi Sun

Pei-Chien Tsai

Matthijs D. van der Zee

Rosie M. Walker

Xiaochuan Wang

Yunzhang Wang

Rui Xia

Zongli Xu

Jie Yao

Wei Zhao

Adolfo Correa

Eric Boerwinkle

Pierre-Antoine Dugué

Peter Durda

Hannah R. Elliott

Christian Gieger

Eco J. C. de Geus

Sarah E. Harris

Gibran Hemani

Medea Imboden

Mika Kähönen

Sharon L. R. Kardia

Jacob K. Kresovich

Shengxu Li

Kathryn L. Lunetta

Massimo Mangino

Dan Mason

机构：

[1] University of Edinburgh,Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer

[2] MRC Integrative Epidemiology Unit University of Bristol,Population Health Sciences, Bristol Medical School

[3] University of Bristol,Department of Human Genetics, David Geffen School of Medicine

[4] University of California Los Angeles,Lothian Birth Cohorts, Department of Psychology

[5] University of Edinburgh,Department of Internal Medicine

[6] Erasmus MC,The Institute for Translational Genomics and Population Sciences, Department of Pediatrics

[7] The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center,Estonian Genome Centre, Institute of Genomics

[8] Swiss Tropical and Public Health Institute,Department of Gynecology and Obstetrics

[9] University of Basel,Longitudinal Study Section, Translational Gerontology Branch

[10] National Institute on Alcohol Abuse and Alcoholism,Research Unit Molecular Epidemiology

[11] National Institutes of Health,Institute of Epidemiology

[12] University of Tartu,TUM School of Medicine

[13] Emory University School of Medicine,Department of Clinical Chemistry

[14] National Institute on Aging,Epidemiology, Biostatistics and Biodemography, Department of Public Health

[15] Helmholtz Zentrum München,Department of Clinical Genetics

[16] German Research Center for Environmental Health,Institute for Molecular Medicine Finland, FIMM, HiLIFE

[17] Helmholtz Zentrum München,Department of Biostatistics

[18] German Research Center for Environmental Health,Department of Genetics

[19] Technical University of Munich,Department of Epidemiology, School of Public Health

[20] Fimlab Laboratories,MRC Centre for Environment and Health, School of Public Health

[21] and Finnish Cardiovascular Research Center - Tampere,Department of Clinical Biochemistry and Pharmacology

[22] Faculty of Medicine and Health Technology,Department of Epidemiology and Biostatistics, School of Public Health

[23] Tampere University,Department of Twin Research and Genetic Epidemiology

[24] University of Southern Denmark,Department of Biomedical Sciences

[25] Odense University Hospital,Division of Pediatric Infectious Diseases, Department of Pediatrics

[26] University of Helsinki,Department of Biological Psychology

[27] University of Alabama at Birmingham,Cancer Epidemiology Division

[28] University of North Carolina at Chapel Hill,Department of Medical Epidemiology and Biostatistics

[29] University of Michigan,The Institute for Translational Genomics and Population Sciences, Department of Pediatrics

[30] Imperial College London,Department of Medicine

[31] Odense University Hospital,School of Public Health

[32] Peking University Health Science Center,Precision Medicine, School of Clinical Sciences at Monash Health

[33] King’s College London,Centre for Epidemiology and Biostatistics

[34] Chang Gung University,Department of Pathology & Laboratory Medicine, Larner College of Medicine

[35] Chang Gung Memorial Hospital,Department of Clinical Physiology

[36] Vrije Universiteit Amsterdam,Children’s Minnesota Research Institute

[37] Amsterdam Public Health Research Institute,Department of Biostatistics

[38] Cancer Council Victoria,Division of Psychiatry

[39] Karolinska Institutet,Section of General Internal Medicine, Department of Medicine

[40] Brown Foundation Institute of Molecular Medicine,TOPMed Data Coordinating Center, Genetic Analysis Center, Department of Biostatistics

[41] McGovern Medical School,Division of Epidemiology and Community Health

[42] University of Texas Health Science Center at Houston,Centre for Population Health Research

[43] National Institute of Environmental Health Sciences,Research Centre of Applied and Preventive Cardiovascular Medicine

[44] The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center,Department of Clinical Physiology and Nuclear Medicine

[45] University of Mississippi Medical Center,Department of Public Health Sciences, Center for Public Health Genomics

[46] University of Texas Health Science Center at Houston,Gerontology Research Center, Faculty of Sport and Health Sciences

[47] Monash University,Department of Psychiatry and Behavioral Sciences

[48] Melbourne School of Population and Global Health,Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center

[49] The University of Melbourne,Chair of Genetic Epidemiology, Institute for Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine

[50] University of Vermont,Department of Epidemiology

来源：

Genome Biology | / 22卷

关键词：

DNA methylation; GWAS; Epigenetic clock;

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