Gold decorated NaYF4:Yb,Er/NaYF4/silica (core/shell/shell) upconversion nanoparticles for photothermal destruction of BE(2)-C neuroblastoma cells

被引：0
|
作者：
Li Peng Qian
Li Han Zhou
Heng-Phon Too
Gan-Moog Chow
机构：
[1] National University of Singapore,Department of Materials Science and Engineering
[2] National University of Singapore,Department of Biochemistry
[3] Singapore–Massachusetts Institute of Technology Alliance,Chemical Pharmaceutical Engineering
来源：
Journal of Nanoparticle Research | 2011年 / 13卷
关键词：
Upconversion; Gold; Photothermal therapy; Nanocomposites; Nanomedicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Gold decorated NaYF4:Yb,Er/NaYF4/silica (core/shell/shell) upconversion (UC) nanoparticles (~70–80 nm) were synthesized using tetraethyl orthosilicate and chloroauric acid in a one-step reverse microemulsion method. Gold nanoparticles (~6 nm) were deposited on the surface of silica shell of these core/shell/shell nanoparticles. The total upconversion emission intensity (green, red, and blue) of the core/shell/shell nanoparticles decreased by ~31% after Au was deposited on the surface of silica shell. The upconverted green light was coupled with the surface plasmon of Au leading to rapid heat conversion. These UC/silica/Au nanoparticles were very efficient to destroy BE(2)-C cancer cells and showed strong potential in photothermal therapy.
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页码：499 / 510
页数：11
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