Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants

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作者：
David N. Springer
Michael Bauer
Iris Medits
Jeremy V. Camp
Stephan W. Aberle
Clemens Burtscher
Eva Höltl
Lukas Weseslindtner
Karin Stiasny
Judith H. Aberle
机构：
[1] Medical University of Vienna,Center for Virology
[2] Erste Bank,Health Center Erste Bank
[3] Medical University of Vienna,Center for Public Health
来源：
npj Vaccines | / 8卷
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摘要：
We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a bivalent BA.1- or BA.4/BA.5-adapted vaccine or had a breakthrough infection with Omicron variants BA.1, BA.2 or BA.4/BA.5. A bivalent BA.4/BA.5 booster or Omicron-breakthrough infection induced increased Omicron-neutralization titers compared with the monovalent booster. The XBB.1.5 variant effectively evaded neutralizing-antibody responses elicited by current vaccines and/or infection with previous variants.
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