Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

被引：0
|
作者：
Guomin Shen
Weidong Cui
Hao Zhang
Fengbo Zhou
Wei Huang
Qian Liu
Yihu Yang
Shuang Li
Gregory R Bowman
J Evan Sadler
Michael L Gross
Weikai Li
机构：
[1] Washington University School of Medicine,Department of Biochemistry and Molecular Biophysics
[2] Washington University in St. Louis,Department of Chemistry
[3] School of Chemistry and Chemical Engineering,Department of Forensic Medicine
[4] Shanghai Jiao Tong University,Division of Hematology, Department of Medicine
[5] Tongji Medical College,undefined
[6] Huazhong University of Science and Technology,undefined
[7] Washington University School of Medicine,undefined
[8] Present addresses: College of Medicine,undefined
[9] Henan University of Science and Technology,undefined
[10] Luoyang,undefined
[11] China (G.S.) and Amgen Inc.,undefined
[12] Cambridge,undefined
[13] Massachusetts,undefined
[14] USA (H.Z.).,undefined
来源：
Nature Structural & Molecular Biology | 2017年 / 24卷
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摘要：
Mass spectrometry and biochemical analyses reveal that the major form of VKOR found in cells features a disulfide bond between Cys51 and Cys132, and this intermediate is the target of the anticoagulant drug warfarin.
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页码：69 / 76
页数：7
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