G protein-coupled receptors: structure- and function-based drug discovery

被引：0

作者：

Dehua Yang

Qingtong Zhou

Viktorija Labroska

Shanshan Qin

Sanaz Darbalaei

Yiran Wu

Elita Yuliantie

Linshan Xie

Houchao Tao

Jianjun Cheng

Qing Liu

Suwen Zhao

Wenqing Shui

Yi Jiang

Ming-Wei Wang

机构：

[1] Chinese Academy of Sciences,The National Center for Drug Screening, Shanghai Institute of Materia Medica

[2] Chinese Academy of Sciences,The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica

[3] Fudan University,School of Basic Medical Sciences

[4] University of Chinese Academy of Sciences,iHuman Institute

[5] ShanghaiTech University,School of Life Science and Technology

[6] ShanghaiTech University,School of Pharmacy

[7] Fudan University,undefined

来源：

Signal Transduction and Targeted Therapy | / 6卷

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摘要：

As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure–function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery.

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