The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies

被引：0
|
作者：
Betül Ünal
Sevil Alan
Cumhur İbrahim Başsorgun
Ayşe Akman Karakaş
Gülsüm Özlem Elpek
Mehmet Akif Çiftçioğlu
机构：
[1] Akdeniz University,Department of Pathology, School of Medicine
[2] Akdeniz University,Department of Dermatology and Venerology, School of Medicine
来源：
Archives of Dermatological Research | 2015年 / 307卷
关键词：
Growth Differentiation Factor-15; GDF-15; MIC-1; Systemic sclerosis; Melanoma; Senescence;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15 is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses, bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15, which is regulated by p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin fibrosis and malignant lesions of the skin.
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页码：551 / 557
页数：6
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