Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

被引：0
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作者：
Larissa Haertle
Tobias Müller
Roy Lardenoije
Anna Maierhofer
Marcus Dittrich
Renzo J. M. Riemens
Samantha Stora
Mathilde Roche
Markus Leber
Steffi Riedel-Heller
Michael Wagner
Martin Scherer
Aimé Ravel
Clotilde Mircher
Cecile Cieuta-Walti
Sophie Durand
Daniel L. A. van de Hove
Per Hoffmann
Alfredo Ramirez
Thomas Haaf
Nady El Hajj
André Mégarbané
机构：
[1] Institute of Human Genetics,Division of Hematology and Oncology, Department of Internal Medicine II
[2] Julius Maximilian University,Department of Bioinformatics
[3] University Hospital,Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience (MHeNs)
[4] Julius Maximilian University,Department of Psychiatry and Psychotherapy
[5] Maastricht University,Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy
[6] University Medical Center Göttingen,Department of Neurodegeneration and Geriatric Psychiatry
[7] Institut Jérôme Lejeune,Institute of Social Medicine, Occupational Health and Public Health
[8] CRB BioJeL,Department of Primary Medical Care
[9] University of Cologne,Department of Psychiatry, Psychosomatics and Psychotherapy
[10] Medical Faculty,Institute of Human Genetics
[11] University of Bonn,Department of Genomics, Life & Brain Center
[12] University of Leipzig,Division of Medical Genetics, University Hospital and Department of Biomedicine
[13] German Center for Neurodegenerative Diseases (DZNE),College of Health and Life Sciences
[14] University Medical Centre Hamburg-Eppendorf,undefined
[15] University of Wuerzburg,undefined
[16] University of Bonn,undefined
[17] University of Bonn,undefined
[18] University of Basel,undefined
[19] Hamad Bin Khalifa University,undefined
[20] Education City,undefined
来源：
Clinical Epigenetics | 2019年 / 11卷
关键词：
Trisomy 21; DNA methylation; Intellectual disability; Down syndrome; Cognitive function; Alzheimer’s disease; Infinium Methylation EPIC arrays;
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