Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

被引：0
|
作者：
I. G. Meerovich
E. V. Sanarova
G. A. Meerovich
V. M. Derkacheva
K. A. Volkov
V. M. Negrimovsky
S. V. Barkanova
E. A. Lukyanets
N. A. Oborotova
Z. S. Smirnova
L. M. Borisova
A. V. Lantsova
A. P. Polozkova
O. L. Orlova
V. B. Loschenov
L. V. Umnova
A. Yu. Baryshnikov
G. N. Vorozhtsov
机构：
[1] N.N. Blokhin Russian Cancer Research Center,Prokhorov Institute of General Physics
[2] Creighton University,undefined
[3] Russian Academy of Sciences,undefined
[4] FSUE SSC “NIOPIK,undefined
[5] ”,undefined
来源：
Russian Journal of General Chemistry | 2015年 / 85卷
关键词：
General Chemistry; Phthalocyanine; Photodynamic Therapy; Lewis Lung Carcinoma; Liposomal Form;
D O I：
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中图分类号：
学科分类号：
摘要：
The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710–740 nm: Thiosens [liposomal form of aluminum hydroxide 1,8,15,22-tetrakis(phenylsulfanyl)phthalocyanine] and Octasens [polymeric micellar form of zinc 1,4,8,11,15,18,22,25-octachloro-2,3,9,10,16,17,23,24-octakis-(decylsulfanyl)phthalocyanine based on domestic poloxamer Emuxol-268]. Experiments have shown that the photosensitizers under study show high selectivity of accumulation and prolonged retaining at high concentration in tumor, relatively fast clearance from normal tissue and high therapeutic efficiency of photodynamic treatment on model tumors.
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页码：280 / 288
页数：8
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