A New Cyclo-Oxygenase-2 Gene Variant in the Han Chinese Population is Associated with an Increased Risk of Gastric Carcinoma

被引：0
|
作者：
Yumin Li
Wenting He
Tao Liu
Quanbao Zhang
机构：
[1] Second Hospital of Lanzhou University,
[2] Key Laboratory of Digestive System,undefined
[3] First Hospital of Lanzhou University,undefined
来源：
Molecular Diagnosis & Therapy | 2010年 / 14卷
关键词：
Gastric Cancer; Pylorus Infection; CagA; Gastric Carcinogenesis; 5939C Allele;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background and Objective: Cyclo-oxygenase-2 (COX-2, also known as prostaglandin synthase 2) influences carcinogenesis through regulation of angiogenesis, apoptosis, and cytokine expression. COX-2 is encoded by the gene PTGS2. Several studies have suggested that PTGS2 single-nucleotide polymorphisms (SNPs) are involved in gastrointestinal carcinogenesis. In this study, we observed the PTGS2 Val511Ala (5939T/C) polymorphism in the Chinese population for the first time, and investigated whether this polymorphism might contribute to gastric cancer in a case-control study conducted in the Gansu province of China, a high-risk area for gastric cancer.
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页码：351 / 355
页数：4
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