Bootstrap-based differential gene expression analysis for RNA-Seq data with and without replicates

被引:0
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作者
Sahar Al Seesi
Yvette Temate Tiagueu
Alexander Zelikovsky
Ion I Măndoiu
机构
[1] University of Connecticut,Computer Science & Engineering Department
[2] Georgia State University,Computer Science Department
来源
BMC Genomics | / 15卷
关键词
differential gene expression; bootstrapping; RNA-Seq;
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摘要
A major application of RNA-Seq is to perform differential gene expression analysis. Many tools exist to analyze differentially expressed genes in the presence of biological replicates. Frequently, however, RNA-Seq experiments have no or very few biological replicates and development of methods for detecting differentially expressed genes in these scenarios is still an active research area.
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