Catalytic Amplification of Electrochemical Signal in Homogeneous Solution Using an Entropy-driven DNA Circuit

被引：0
|
作者：
Yusuke Kitamura
Keisuke Yoshimura
Ryo Kuramoto
Yousuke Katsuda
Toshihiro Ihara
机构：
[1] Kumamoto University,Division of Materials Science, Faculty of Advanced Science and Technology
来源：
Analytical Sciences | 2021年 / 37卷
关键词：
Nucleic acids; electrochemical biosensor; inclusion complex; ferrocene; cyclodextrin; homogeneous assay; DNA circuit; signal amplification;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The electrochemical signal from ferrocene on a DNA probe was successfully modulated in a homogeneous solution by the template-directed formation and dissociation of an inclusion complex with β-cyclodextrin on another probe. The electrochemical response was amplified by combining with a DNA circuit, in which the target DNA served as a catalyst. This system did not require any modification of a complementary DNA with the ferrocene-modified probe on the electrode surface to separate the bound/free probe for the detection of 200 nM target DNA.
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页码：533 / 537
页数：4
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