A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys

被引：0
|
作者：
Xiao Fang
Xiong Fang
Yujia Mao
Aaron Ciechanover
Yan Xu
Jing An
Ziwei Huang
机构：
[1] Tsinghua University,School of Life Sciences
[2] Technion-Israel Institute of Technology,The Rapport Faculty of Medicine
[3] Nobel Institute of Biomedicine,Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences
[4] Chinese University of Hong Kong,Division of Infectious Diseases and Global Public Health, Department of Medicine, School of Medicine
[5] University of California at San Diego,undefined
来源：
Stem Cell Research & Therapy | / 12卷
关键词：
Hematopoietic stem cell mobilization; CXCR4 antagonist; Monkeys; Hematopoietic stem cell transplantation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
    Rubin, JB
    Kung, AL
    Klein, RS
    Chan, JA
    Sun, YP
    Schmidt, K
    Kieran, MW
    Luster, AD
    Segal, RA
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) : 13513 - 13518
  • [32] Small molecule CXCR4 antagonist accelerates reendothelialization by mobilization of bone marrow-derived endothelial progenitor cells
    Iwakura, A
    Leudemann, C
    Bridger, G
    Asahara, T
    CIRCULATION, 2004, 110 (17) : 33 - 33
  • [33] Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial
    Karpova, Darja
    Braeuninger, Susanne
    Wiercinska, Eliza
    Kraemer, Ariane
    Stock, Belinda
    Graff, Jochen
    Martin, Hans
    Wach, Achim
    Escot, Christophe
    Douglas, Garry
    Romagnoli, Barbara
    Chevalier, Eric
    Dembowski, Klaus
    Hooftman, Leon
    Bonig, Halvard
    JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15
  • [34] Development of a Unique Small Molecule Modulator of CXCR4
    Liang, Zhongxing
    Zhan, Weiqiang
    Zhu, Aizhi
    Yoon, Younghyoun
    Lin, Songbai
    Sasaki, Maiko
    Klapproth, Jan-Michael A.
    Yang, Hua
    Grossniklaus, Hans E.
    Xu, Jianguo
    Rojas, Mauricio
    Voll, Ronald J.
    Goodman, Mark M.
    Arrendale, Richard F.
    Liu, Jin
    Yun, C. Chris
    Snyder, James P.
    Liotta, Dennis C.
    Shim, Hyunsuk
    PLOS ONE, 2012, 7 (04):
  • [35] Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
    Liles, WC
    Broxmeyer, HE
    Rodger, E
    Wood, B
    Hübel, K
    Cooper, S
    Hangoc, G
    Bridger, GJ
    Henson, GW
    Calandra, G
    Dale, DC
    BLOOD, 2003, 102 (08) : 2728 - 2730
  • [36] MOBILIZATION OF HEMATOPOIETIC PROGENITOR CELLS FOR AUTOLOGOUS TPH WITH CXCR4 ANTAGONIST: EXPERIENCE IN OUR HOSPITAL
    Moreno Vega, M. M.
    Lopez Brito, J.
    Guerra Dominguez, L.
    Naylen, C.
    Molero Labarta, T.
    HAEMATOLOGICA, 2015, 100 : 290 - 291
  • [37] Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4
    M P Rettig
    G Ansstas
    J F DiPersio
    Leukemia, 2012, 26 : 34 - 53
  • [38] Development of VLA4 and CXCR4 Antagonists for the Mobilization of Hematopoietic Stem and Progenitor Cells
    Ruminski, Peter G.
    Rettig, Michael P.
    DiPersio, John F.
    BIOMOLECULES, 2024, 14 (08)
  • [39] Effective mobilization of hematopoietic stem cells with a small molecule α9β1/α4β1 integrin antagonist
    Grassinger, J.
    Cao, B.
    Zhang, Z.
    Klatt, S.
    Williams, B.
    Mueller, G.
    Hart, C.
    Schelker, R.
    Herr, W.
    Nilsson, S. K.
    Oncology Research and Treatment, 2015, 38 : 103 - 103
  • [40] Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4
    Rettig, M. P.
    Ansstas, G.
    DiPersio, J. F.
    LEUKEMIA, 2012, 26 (01) : 34 - 53
12345