Primer: epigenetics of autoimmunity

被引：0
|
作者：
Bruce Richardson
机构：
[1] B Richardson is Professor of Medicine at the University of Michigan and Chief of the Section of Rheumatology at the Ann Arbor Veterans Affairs Hospital,
[2] Ann Arbor,undefined
[3] MI,undefined
[4] USA.,undefined
来源：
Nature Clinical Practice Rheumatology | 2007年 / 3卷
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D O I：
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学科分类号：
摘要：
Epigenetic mechanisms, including DNA methylation and histone modifications, control regional chromatin structure and thereby influence gene expression. In this Review, Dr Richardson discusses the association between epigenetics, environmental factors, and the development of autoimmune diseases, in particular systemic lupus erythematosus, in genetically predisposed individuals.
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页码：521 / 527
页数：6
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