Polyfunctional imidazoles: VII. 1-aryl-4-chloro-5-[hydroxy(halo)methyl]-1H-imidazoles and their derivatives

被引：0
|
作者：
V. A. Chornous
A. N. Grozav
D. V. Klyukovskii
A. V. Bezdudnyi
M. V. Vovk
机构：
[1] Bukovina State Medical University,Institute of Organic Chemistry
[2] National Academy of Sciences of Ukraine,undefined
来源：
Russian Journal of Organic Chemistry | 2013年 / 49卷
关键词：
Imidazole; Chloromethyl; Sulfanyl; Sodium Hydrogen Carbonate; Ylmethyl;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The reduction of 1-aryl-4-chloro-1H-imidazole-5-carbaldehydes with sodium tetrahydridoborate gave 1-aryl-4-chloro-1H-imidazol-5-ylmethanols which were converted into 5-chloromethyl and 5-fluoromethyl derivatives. 1-Aryl-4-chloro-5-chloromethyl-1H-imidazoles reacted with sodium azide, secondary amines, thiols, and triphenylphosphine to produce the corresponding products of chlorine replacement in the 5-chloromethyl group.
引用
收藏
页码：568 / 574
页数：6
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