Association of HLA-DRB1, DQB1 alleles with chronic urticaria

被引：0
|
作者：
Chen Jing
Tan Zhijian
Li Liawen
Xiong Ping
机构：
[1] Huangzhong University of Science and Technology,Department of Dermatology, Union Hospital, Tongji Medical College
来源：
Current Medical Science | 2005年 / 25卷 / 3期
关键词：
urticaria, chronic; genes, MHC class II; polymerase chain reaction-sequence specific primer;
D O I：
10.1007/BF02828166
中图分类号：
学科分类号：
摘要：
In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67±12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1* 12. * 0901 (RR=3.11, χ2=7.579,P=0.006; RR=2.47, χ2=5.684,P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1 * 05 (RR=0.26, χ2=6.683,P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1 * 12, * 0901 and HLA-DQB1 * 05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.
引用
收藏
页码：354 / 356
页数：2
相关论文
共 50 条
  • [31] HLA-DRB1*1501,-DQB1*0301,-DQB1*0302,-DQB1*0602, and-DQB1*0603 alleles are associated with more severe disease outcome on MRI in patients with multiple sclerosis
    Zivadinov, Robert
    Uxa, Laura
    Bratina, Alessio
    Bosco, Antonio
    Srinivasaraghavan, Bhooma
    Minagar, Alireza
    Ukmar, Maja
    Benedetto, Su yen
    Zorzon, Marino
    [J]. NEUROBIOLOGY OF MULTIPLE SCLEROSIS, 2007, 79 : 521 - 535
  • [32] HLA-DRB1 and DQB1 genes in Japanese patients with systemic sclerosis
    Akimoto, S
    Abe, M
    Ishikawa, O
    [J]. JOURNAL OF RHEUMATOLOGY, 2000, 27 (12) : 2940 - 2942
  • [33] Association of HLA class II DQB1 and DRB1 alleles with breast cancer in Tunisia
    不详
    [J]. EUROPEAN CYTOKINE NETWORK, 2004, 15 (04) : VII - VII
  • [34] Association of HLA DRB1, DQB1 and DQA1 alleles with autoimmune endocrine disease
    Weinstock, Christof
    Haager, Marie-Christine
    Barkia, Sirine
    Matheis, Nina
    Janson, Anne
    Markovic, Alexander
    Kahaly, George J.
    Bux, Juergen
    [J]. TISSUE ANTIGENS, 2009, 73 (05): : 493 - 494
  • [35] Association of HLA-DRB1 and DQB1 polymorphisms with severe hepatitis C virus infection.
    He, JQ
    Nelson, K
    Carithers, RL
    Gaur, IK
    [J]. HEPATOLOGY, 2003, 38 (04) : 528A - 529A
  • [36] HLA-DRB1, -DQB1 and -DPB1 polymorphism in the Slovak population
    Cechová, E
    Fazekasová, H
    Ferencík, S
    Shawkatová, I
    Buc, M
    [J]. TISSUE ANTIGENS, 1998, 51 (05): : 574 - 576
  • [37] Association of HLA-DRB1 and-DQB1 alleles and haplotypes with rheumatoid arthritis in a Pakistani population
    Muazzam, Ambreen Gul
    Mansoor, Atika
    Ali, Lubna
    Siddiqi, Saima
    Hameed, Abdul
    Ajmal, Muhammad
    Mazhar, Kehkashan
    [J]. ARTHRITIS RESEARCH & THERAPY, 2013, 15 (04)
  • [38] Association of HLA-DRB1 and-DQB1 Alleles with Susceptibility to IgA Nephropathy in Korean Patients
    In, Ji Won
    Jung, Kiwook
    Shin, Sue
    Park, Kyoung Un
    Lee, Hajeong
    Song, Eun Young
    [J]. ANNALS OF LABORATORY MEDICINE, 2022, 42 (01) : 54 - 62
  • [39] High-resolution molecular characterization of HLA-DRB1*,-DQB1*alleles and their haplotypic combinations in a Greek population
    Kitsiou, V.
    Kouniaki, D.
    Athanassiades, T.
    Tarassi, K.
    Galaziou, G.
    Bekyros, V.
    Papasteriades, C.
    [J]. TISSUE ANTIGENS, 2008, 72 (03): : 272 - 272
  • [40] Association of HLA-DRB1 and -DQB1alleles and haplotypes with rheumatoid arthritis in a Pakistani population
    Ambreen Gul Muazzam
    Atika Mansoor
    Lubna Ali
    Saima Siddiqi
    Abdul Hameed
    Muhammad Ajmal
    Kehkashan Mazhar
    [J]. Arthritis Research & Therapy, 15
12345