SMART Thinking: a Review of Recent Developments in Sequential Multiple Assignment Randomized Trials

被引：0
|
作者：
Michael P. Wallace
Erica E. M. Moodie
David A. Stephens
机构：
[1] McGill University,Department of Epidemiology, Biostatistics and Occupational Health
[2] McGill University,Department of Mathematics and Statistics
来源：
Current Epidemiology Reports | 2016年 / 3卷 / 3期
关键词：
SMARTs; Dynamic treatment regimes; Adaptive treatment strategies; Longitudinal data; Causal inference;
D O I：
10.1007/s40471-016-0079-3
中图分类号：
学科分类号：
摘要：
With the increasing interest in personalized medicine, over the last decade, sequential multiple assignment randomized trials (SMARTs) have become a more common fixture of the clinical trial landscape. Primarily of use in the identification of dynamic treatment regimes, they have experienced a shift from the more complex designs of the past to the considerably streamlined versions seen today. In this review, we summarize their history, outline recent and ongoing examples, and discuss some of the important methodological developments for their design and implementation.
引用
收藏
页码：225 / 232
页数：7
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