Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma

被引：0

作者：

Routila, E. ^{[1
,2
,3
]}

Mahran, R. ^{[1
,3
,4
]}

Salminen, S. ^{[1
,3
]}

Irjala, H. ^{[5
,6
]}

Haapio, E. ^{[5
,6
]}

Kyto, E. ^{[5
,6
]}

Ventela, S. ^{[3
,5
,6
,7
,8
]}

Petterson, K. ^{[1
]}

Routila, J. ^{[3
,5
,6
]}

Gidwani, K. ^{[1
]}

Leivo, J. ^{[1
,2
,3
]}

机构：

[1] Univ Turku, Dept Life Technol, Kiinamyllynkatu 10, Turku 20520, Finland

[2] Univ Turku, InFLAMES Res Flagship, Turku 20014, Finland

[3] FICAN West Canc Ctr, Turku, Finland

[4] Univ Turku, Dept Chem, Henrikinkatu 2, Turku 20500, Finland

[5] Univ Turku, Dept Otorhinolaryngol Head & Neck Surg, Savitehtaankatu 5, Turku 20520, Finland

[6] Turku Univ Hosp, Savitehtaankatu 5, Turku 20520, Finland

[7] Univ Turku, Turku Biosci Ctr, Tykistokatu 6, Turku 20520, Finland

[8] Abo Akad Univ, Tykistokatu 6, Turku 20520, Finland

来源：

BMC CANCER | 2024年 / 24卷 / 01期

关键词：

HNSCC; Stemness; Glycosylation; Lectin; Bioaffinity assay; ORAL PRECANCEROUS CONDITIONS; CANCER;

D O I：

10.1186/s12885-024-12161-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.Methods Tumor, adjacent normal tissue, and blood samples of 25 patients were collected together with clinical details. After tissue processing, lectin-based glycovariant screens were performed.Results Strong correlation between glycosylation profiles of all four stemness-related proteins was observed in tumor tissue, whereas glycosylation in tumor tissue, adjacent normal tissue, and serum was differential.Conclusions A mannose- and galactose-rich glycosylation niche associated with stemness-related proteins was identified.

引用

页数：11

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