Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma

被引：0
|
作者：
Routila, E. [1 ,2 ,3 ]
Mahran, R. [1 ,3 ,4 ]
Salminen, S. [1 ,3 ]
Irjala, H. [5 ,6 ]
Haapio, E. [5 ,6 ]
Kyto, E. [5 ,6 ]
Ventela, S. [3 ,5 ,6 ,7 ,8 ]
Petterson, K. [1 ]
Routila, J. [3 ,5 ,6 ]
Gidwani, K. [1 ]
Leivo, J. [1 ,2 ,3 ]
机构：
[1] Univ Turku, Dept Life Technol, Kiinamyllynkatu 10, Turku 20520, Finland
[2] Univ Turku, InFLAMES Res Flagship, Turku 20014, Finland
[3] FICAN West Canc Ctr, Turku, Finland
[4] Univ Turku, Dept Chem, Henrikinkatu 2, Turku 20500, Finland
[5] Univ Turku, Dept Otorhinolaryngol Head & Neck Surg, Savitehtaankatu 5, Turku 20520, Finland
[6] Turku Univ Hosp, Savitehtaankatu 5, Turku 20520, Finland
[7] Univ Turku, Turku Biosci Ctr, Tykistokatu 6, Turku 20520, Finland
[8] Abo Akad Univ, Tykistokatu 6, Turku 20520, Finland
来源：
BMC CANCER | 2024年 / 24卷 / 01期
关键词：
HNSCC; Stemness; Glycosylation; Lectin; Bioaffinity assay; ORAL PRECANCEROUS CONDITIONS; CANCER;
D O I：
10.1186/s12885-024-12161-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.Methods Tumor, adjacent normal tissue, and blood samples of 25 patients were collected together with clinical details. After tissue processing, lectin-based glycovariant screens were performed.Results Strong correlation between glycosylation profiles of all four stemness-related proteins was observed in tumor tissue, whereas glycosylation in tumor tissue, adjacent normal tissue, and serum was differential.Conclusions A mannose- and galactose-rich glycosylation niche associated with stemness-related proteins was identified.
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页数：11
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