De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis

被引：0
|
作者：
Polly M Fordyce
Doron Gerber
Danh Tran
Jiashun Zheng
Hao Li
Joseph L DeRisi
Stephen R Quake
机构：
[1] University of California,Department of Biochemistry and Biophysics
[2] San Francisco,Department of Life Sciences
[3] Howard Hughes Medical Institute,Departments of Bioengineering and Applied Physics
[4] Bar Ilan University,undefined
[5] Stanford University,undefined
[6] Center for Theoretical Biology,undefined
[7] Peking University,undefined
来源：
Nature Biotechnology | 2010年 / 28卷
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学科分类号：
摘要：
Fordyce et al. measure the sequence specificity and affinity of DNA-binding proteins using an improved microfluidic device. They characterize binding of 28 yeast transcription factors, several of which had proved intractable to previous approaches.
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页码：970 / 975
页数：5
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