Natural killer (NK) cells participate in cancer immunosurveillance and cancer immunotherapy. Live cell imaging of cancer cells targeted by NK cells, published today in BMC Biology by Zhu et al., reveals a remarkable diversity of programmed cell death pathways induced in individual cells. Pathway choice depends on the state of the target cell actin cytoskeleton and a novel death pathway, granzyme-induced necroptosis, could be of broad importance in cancer immunotherapy.
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Univ Wisconsin, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USAUniv Wisconsin, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USA
Amos-Landgraf, James M.
Clipson, Linda
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Univ Wisconsin, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USAUniv Wisconsin, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USA
Clipson, Linda
Newton, Michael A.
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Univ Wisconsin, Dept Stat, Madison, WI 53706 USA
Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI USAUniv Wisconsin, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USA
Newton, Michael A.
Dove, William F.
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Univ Wisconsin, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USA
Univ Wisconsin, Genet Lab, Madison, WI 53706 USAUniv Wisconsin, McArdle Lab Canc Res, Dept Oncol, Madison, WI 53706 USA