One-pot synthesis of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines and their reactions

被引：0
|
作者：
A. H. Moustafa
A. S. Shestakov
Kh. S. Shikhaliev
机构：
[1] Voronezh State University,
来源：
Chemistry of Heterocyclic Compounds | 2012年 / 48卷
关键词：
cyanamide; -cyanoimine; dihydropyrimidine; alkylation; Biginelli reaction; oxidation;
D O I：
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学科分类号：
摘要：
A series of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines was obtained as a result of a multicomponent Biginelli reaction using 1,3-dicarbonyl compounds, aromatic aldehydes, and cyanamide. Alkylation of the obtained compounds with benzyl chloride takes place at the two nitrogen atoms of the tetrahydropyrimidine ring, while oxidation with manganese dioxide leads to the corresponding 1-(pyrimidin-2-yl)carbamides or pyrimidine-2-amines, depending on the conditions.
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页码：613 / 619
页数：6
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