Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

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作者：
Gowoon Son
Thomas C. Neylan
Lea T. Grinberg
机构：
[1] University of California,Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology
[2] San Francisco,Department of Psychiatry
[3] University of California,Global Brain Health Institute
[4] San Francisco,Department of Pathology
[5] University of California,Department of Pathology
[6] San Francisco,undefined
[7] University of Sao Paulo Medical School,undefined
[8] University of California,undefined
[9] San Francisco,undefined
来源：
Molecular Neurodegeneration | / 19卷
关键词：
“Alzheimer’s disease”; “Progressive supranuclear palsy”; “Neurodegenerative disease”; “Suprachiasmatic nucleus”; “Tau”; “Amyloid”; “Circadian dysregulation”; “Circadian clock”; “Astrocyte”; “Microglia”;
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摘要：
Tauopathies, a group of neurodegenerative diseases that includes Alzheimer’s disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-hour cycle governing human biological activity, is regulated by the hypothalamic suprachiasmatic nucleus (SCN) and endogenous transcriptional-translational feedback loops. Surprisingly, little attention has been given to investigating tauopathy-driven neuropathology in the SCN and the repercussions of SCN and circadian gene dysfunction in the human brain affected by tauopathies. This review aims to provide an overview of the current literature on the vulnerability of the SCN in tauopathies in humans. Emphasis is placed on elucidating the neuronal and glial changes contributing to the widespread disruption of the molecular circadian clock. Furthermore, this review identifies areas of knowledge requiring further investigation.
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