Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

被引：0
|
作者：
Oscar R. Colegio
Ngoc-Quynh Chu
Alison L. Szabo
Thach Chu
Anne Marie Rhebergen
Vikram Jairam
Nika Cyrus
Carolyn E. Brokowski
Stephanie C. Eisenbarth
Gillian M. Phillips
Gary W. Cline
Andrew J. Phillips
Ruslan Medzhitov
机构：
[1] Yale University School of Medicine,Department of Immunobiology
[2] Yale University School of Medicine,Department of Dermatology
[3] Yale-New Haven Transplantation Center,Department of Laboratory Medicine
[4] Yale University School of Medicine,Department of Chemistry
[5] Yale Cancer Center,Department of Internal Medicine
[6] Yale University School of Medicine,undefined
[7] Yale University School of Medicine,undefined
[8] Yale University School of Medicine,undefined
[9] Yale University School of Medicine,undefined
[10] Howard Hughes Medical Institute,undefined
来源：
Nature | 2014年 / 513卷
关键词：
D O I：
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中图分类号：
学科分类号：
摘要：
The growth of tumours is supported by tumour production of lactic acid, which polarizes tumour-associated macrophages to an M2 phenotype through a pathway dependent on hypoxia-inducible factor 1α.
引用
收藏
页码：559 / 563
页数：4
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