Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

被引：0

作者：

Sergey Nejentsev

Joanna M. M. Howson

Neil M. Walker

Jeffrey Szeszko

Sarah F. Field

Helen E. Stevens

Pamela Reynolds

Matthew Hardy

Erna King

Jennifer Masters

John Hulme

Lisa M. Maier

Deborah Smyth

Rebecca Bailey

Jason D. Cooper

Gloria Ribas

R. Duncan Campbell

David G. Clayton

John A. Todd

机构：

[1] Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory,Department of Medical Genetics

[2] Cambridge Institute of Medical Research,Department of Physiology Anatomy and Genetics

[3] University of Cambridge,Department of Health Sciences

[4] MRC Rosalind Franklin Centre for Genomics Research,Department of Medical Genetics

[5] Hinxton,Department of Psychological Medicine

[6] Cambridge,Department of Haematology

[7] CB10 1SB,Department of Cardiovascular Sciences

[8] UK ,Department of Statistics

[9] University of Oxford,Division of Community Health Services

[10] Genetic Epidemiology Group,Department of Psychiatry, Division of Neuroscience

[11] University of Leicester,Department of Psychological Medicine

[12] Adrian Building,Department of Medical & Molecular Genetics

[13] University Road,Department of Gastroenterology

[14] Leicester LE1 7RH,Department of Gastroenterology & Hepatology

[15] UK.,Department of Paediatrics

[16] Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory,Department of Medicine, Division of Medical Sciences

[17] Cambridge Institute for Medical Research,undefined

[18] University of Cambridge,undefined

[19] Wellcome Trust/MRC Building,undefined

[20] Cambridge CB2 0XY,undefined

[21] UK.,undefined

[22] Wellcome Trust Centre for Human Genetics,undefined

[23] University of Oxford,undefined

[24] Roosevelt Drive,undefined

[25] Oxford OX3 7BN,undefined

[26] UK.,undefined

[27] Henry Wellcome Building,undefined

[28] School of Medicine,undefined

[29] Cardiff University,undefined

[30] Heath Park,undefined

[31] Cardiff CF14 4XN,undefined

[32] UK.,undefined

[33] The Wellcome Trust Sanger Institute,undefined

[34] Wellcome Trust Genome Campus,undefined

[35] Hinxton,undefined

[36] Cambridge CB10 1SA,undefined

[37] UK.,undefined

[38] The Wellcome Trust,undefined

[39] Gibbs Building,undefined

[40] 215 Euston Road,undefined

[41] London NW1 2BE,undefined

[42] UK.,undefined

[43] Oxford Centre for Diabetes,undefined

[44] Endocrinology and Medicine,undefined

[45] University of Oxford,undefined

[46] Churchill Hospital,undefined

[47] Oxford OX3 7LJ,undefined

[48] UK.,undefined

[49] University of Cambridge,undefined

[50] Long Road,undefined

来源：

Nature | 2007年 / 450卷

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摘要：

The MHC complex, occupying a sizeable section of human chromosome 6, is linked to almost all known autoimmune disorders. A new study uses a large data set from the Wellcome Trust Case Control Consortium to focus more closely on the MHC genes linked to a specific disease, childhood diabetes. Two susceptibility genes emerge: HLA-A and HLA-B. The discovery clarifies the aetiology of type 1 diabetes and points to a class of peptides worth studying in the search for vaccination strategies.

引用

页码：887 / 892

页数：5

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