Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

被引:0
|
作者
Jimmy Fourtounis
I-Ming Wang
Marie-Claude Mathieu
David Claveau
Tenneille Loo
Aimee L Jackson
Mette A Peters
Alex G Therien
Yves Boie
Michael A Crackower
机构
[1] Merck Research Laboratories,Department of Respiratory and Immunology
[2] Merck Research Laboratories,Exploratory and Translational Sciences
[3] Merck Research Laboratories,Infectious Diseases
来源
Respiratory Research | / 13卷
关键词
Asthma; NRF2; KEAP1; Oxidative stress; Eotaxin regulation; Microarray profiling;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer: Nrf2 Expression is Closely Correlated to Keap1 in the Tumor and Bach1 in the Normal Tissue
    Chang, Liang-Che
    Fan, Chung-Wei
    Tseng, Wen-Ko
    Chen, Jim-Ray
    Chein, Hui-Ping
    Hwang, Cheng-Cheng
    Hua, Chung-Ching
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2013, 21 (06) : 511 - 517
  • [22] Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia
    Bowles, Kristian M.
    Rushworth, Stuart A.
    MOLECULAR & CELLULAR ONCOLOGY, 2018, 5 (03)
  • [23] Metal profiling in coronary ischemia-reperfusion injury: Implications for KEAP1/NRF2 regulated redox signaling
    Yang, Fan
    Smith, Matthew J.
    FREE RADICAL BIOLOGY AND MEDICINE, 2024, 210 : 158 - 171
  • [24] Loss Of Keap1 Leads To Increased Levels Of Nrf2 And Nrf2-Dependent Antioxidant Gene Expression During Hyperoxia-Induced Lung Epithelial Cell Death
    Potteti, H. R.
    Reddy, N. M.
    Reddy, S. P.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [25] Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease
    Korytina, Gulnaz F.
    Akhmadishina, Leysan Z.
    Aznabaeva, Yulia G.
    Kochetova, Olga V.
    Zagidullin, Naufal Sh.
    Kzhyshkowska, Julia G.
    Zagidullin, Shamil Z.
    Viktorova, Tatyana V.
    GENE, 2019, 692 : 102 - 112
  • [26] Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
    Meiling Gong
    Yan Li
    Xiaoping Ye
    Linlin Zhang
    Zhifang Wang
    Xiaowen Xu
    Yejing Shen
    Cuixia Zheng
    Cell Communication and Signaling, 18
  • [27] Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia
    Akin-Bali, Dilara Fatma
    Aktas, Sedef Hande
    Unal, Mehmet Altay
    Kankilic, Teoman
    PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2020, 37 (01) : 58 - 75
  • [28] KEAP1 gene editing using CRISPR/Cas9 for therapeutic NRF2 activation in human T cells
    Noel, Sanjeev
    Lee, Sul A.
    Sadasivam, Mohanraj
    Hamad, Abdel Rahim A.
    Rabb, Hamid
    JOURNAL OF IMMUNOLOGY, 2017, 198 (01):
  • [29] A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90
    Ngo, Vy
    Brickenden, Anne
    Liu, Hansen
    Yeung, Cynthia
    Choy, Wing-Yiu
    Duennwald, Martin L.
    DISEASE MODELS & MECHANISMS, 2022, 15 (04)
  • [30] Bis-Michael Acceptors as Novel Probes to Study the Keap1/Nrf2/ARE Pathway
    Deny, Ludovic J.
    Traboulsi, Hussein
    Cantin, Andre M.
    Marsault, Eric
    Richter, Martin V.
    Belanger, Guillaume
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (20) : 9431 - 9442