Effects of Pharmaceutical Preparations on the Rate of Degradation of Poly(Lactide-Co-Glycolide) Scaffolds

被引：0
|
作者：
E. N. Antonov
A. G. Dunaev
S. A. Minaeva
L. I. Krotova
V. K. Popov
机构：
[1] Russian Academy of Sciences,Institute of Photon Technologies, Crystallography and Photonics Federal Science Research Center
来源：
Pharmaceutical Chemistry Journal | 2018年 / 52卷
关键词：
acetylsalicylic acid; ibuprofen; 6-methyluracil; chondroitin sulfate; poly(lactide-co-glycolides); scaffolds; supercritical carbon dioxide; hydrolysis constants;
D O I：
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学科分类号：
摘要：
The effects of acetylsalicylic acid, ibuprofen, 6-methyluracil, and chondroitin sulfate impregnated in poly-(lactide-co-glycolide) scaffolds of different chemical compositions and molecular weights using supercritical carbon dioxide on the processes of scaffold degradation in phosphate-buffered saline pH 7.4 were studied and the rate constants of these processes were determined. Incorporation of acetylsalicylic acid and ibuprofen into poly(lactide-co-glycolide) scaffolds was found to produce significant increases in the rate of hydrolysis of the polymer base, while the presence of methyluracil and chondroitin sulfate had virtually no effect.
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页码：69 / 76
页数：7
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