Chitosan/poly(dl,lactide-co-glycolide) scaffolds for tissue engineering

被引：0
|
作者：
S. A. Martel-Estrada
I. Olivas-Armendáriz
C. A. Martínez-Pérez
T. Hernández
E. I. Acosta-Gómez
J. G. Chacón-Nava
F. Jiménez-Vega
P. E. García-Casillas
机构：
[1] Universidad Autónoma de Cd. Juárez,Instituto de Ingeniería y Tecnología
[2] University of Wisconsin-Madison,Physics Department
[3] Universidad Autónoma de Ciudad Juárez,Instituto de Ciencias Biomédicas
[4] Centro de Investigación en Materiales Avanzados,Departamento de Integridad y Desarrollo de Materiales Compuestos
来源：
Journal of Materials Science: Materials in Medicine | 2012年 / 23卷
关键词：
Chitosan; Tissue Engineering; Lactide; Osteocalcin; Composite Scaffold;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chitosan/poly(dl-lactide-co-glycolide) (Ch/dl PLG) composite scaffolds were fabricated by freeze-drying lyophilization, and were evaluated and compared for use as a bone regeneration scaffold through measurements of the compression mechanical properties of the porous scaffolds. Also, In vitro cell culture of Sprague–Dawley rat’s osteoblasts were used to evaluate the phenotype expression of cells in the scaffolds, characterizing the cellular adhesion, proliferation and alkaline phosphatase activity. The gene expression of osteocalcin, sialoprotein, alkaline phosphatase, Type I collagen and TGFβ1 were confirmed in the samples; moreover, it was confirmed, the mineralization by IR spectra and EDS analysis. Our results thus show that Ch/dl PLG scaffolds are suitable for biological applications.
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页码：2893 / 2901
页数：8
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