Synthesis and crystal structures of cis- and trans-1-(3′-N, N-dimethylthiocarbamoyl-4′-methoxy)-2-(3″, 4″, 5″trimethoxyphenyl) ethene

被引：0

作者：

Daniel A. Ramirez

Jianxing Zhang

Kevin Klausmeyer

Robert R. Kane

机构：

[1] Baylor University,Department of Chemistry and Biochemistry and the Center for Drug Discovery

来源：

Journal of Chemical Crystallography | 2005年 / 35卷

关键词：

combretastatin; stilbene; thiocarbamate;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The combretastatin A-4 analogue cis-1-(3′-N,N-dimethylthiocarbamoyl-4′-methoxy)-2-(3″,4″, 5″-trimethoxyphenyl) ethene (1) and its trans stereoisomer (2) were synthesized. The molecular structures of these compounds were obtained by single-crystal X-ray diffraction. Crystallization of 1 occurs in the centrosymmetric monoclinic space group C2/c (No. 15) with a = 21.468(5), b = 7.932(1), c = 23.949(3); and β = 100.75(1)∘ and Z = 8. Crystallization of 2 occurs in the centrosymmetric monoclinic space group P21/n (No. 14) with a = 11.7825(7), b = 11.562(1), c = 14.911(1) and β = 93.294(6); and Z = 4. Details of the synthesis and the structural characterization of the title compounds are presented and discussed.

引用

页码：227 / 232

页数：5

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