Mechanical and Physical-Technological Properties of Gelatin Ribbon in the Manufacture of Soft Gelatin Capsules

被引:0
|
作者
E. I. Molokhova
E. I. Ponomareva
A. A. Adamov
A. K. Kholov
机构
[1] Perm State Pharmaceutical Academy,Institute of Continuous Medium Mechanics, Urals Department
[2] Russian Academy of Sciences,State Science Research Institute of Nutrition
[3] Ministry of Energy and Industry of the Republic of Tajikistan,undefined
来源
关键词
soft gelatin capsules: mechanical properties; rheology;
D O I
暂无
中图分类号
学科分类号
摘要
The mechanical properties of gelatin ribbon and the rheology of bulk gelatin in the manufacture of soft gelatin capsules were studied. The results provide evidence that retention of the strength and elasticity of capsule casings during the manufacturing process and storage requires Young’s modulus of the gelatin ribbon to be in the range 35 – 50 MPa, the elongation at breaking being 210 – 240% and the tensile strength being 8 – 9 MPa. The studies also showed that regenerated gelatin stock loses its structural-mechanical properties, particularly its strength and plasticity, which can lead to failure of gelatin capsules during storage and drying.
引用
收藏
页码:644 / 647
页数:3
相关论文
共 50 条
  • [21] EFFECT OF STORAGE-TEMPERATURE ON THE PHYSICOCHEMICAL PROPERTIES OF SOFT GELATIN CAPSULE SHELLS .6. STUDIES ON SOFT GELATIN CAPSULES
    HAKATA, T
    SATO, H
    WATANABE, Y
    MATSUMOTO, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (07) : 1496 - 1500
  • [22] Pure food gelatin - Physical properties related to the economy of manufacture
    Briefer, M
    Cohen, JH
    INDUSTRIAL AND ENGINEERING CHEMISTRY, 1928, 20 (01): : 408 - 413
  • [23] FORMULATION AND PHYSICAL-PROPERTIES OF THIXOTROPIC GELS FOR HARD GELATIN CAPSULES
    WALTERS, PA
    ROWLEY, G
    PEARSON, JT
    TAYLOR, CJ
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1992, 18 (15) : 1613 - 1631
  • [24] The Effect of Gelatin Cross-Linking on the Bioequivalence of Hard and Soft Gelatin Acetaminophen Capsules
    Marvin C. Meyer
    Arthur B. Straughn
    Ramakant M. Mhatre
    Ajaz Hussain
    Vinod P. Shah
    Carey B. Bottom
    Ewart T. Cole
    Larry L. Lesko
    Henry Mallinowski
    Roger L. Williams
    Pharmaceutical Research, 2000, 17 : 962 - 966
  • [25] The effect of gelatin cross-linking on the bioequivalence of hard and soft gelatin acetaminophen capsules
    Meyer, MC
    Straughn, AB
    Mhatre, RM
    Hussain, A
    Shah, VP
    Bottom, CB
    Cole, ET
    Lesko, LL
    Mallinowski, H
    Williams, RL
    PHARMACEUTICAL RESEARCH, 2000, 17 (08) : 962 - 966
  • [27] Hypersensitivity to gelatin used as excipient for soft capsules of Ibuprofen
    Heffler, E.
    Guida, G.
    Badiu, I
    Pizzimenti, S.
    Bergia, R.
    Bommarito, L.
    Nebiolo, F.
    Rolla, G.
    ALLERGY, 2008, 63 : 110 - 110
  • [28] Shell Formulation in Soft Gelatin Capsules: Design and Characterization
    Naharros-Molinero, Almudena
    Caballo-Gonzalez, Maria angela
    de la Mata, F. Javier
    Garcia-Gallego, Sandra
    ADVANCED HEALTHCARE MATERIALS, 2024, 13 (01)
  • [29] DETERMINATION OF CHLORAL HYDRATE IN SOFT GELATIN CAPSULES BY NMR
    TURCZAN, JW
    GOLDWITZ, BA
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1972, 61 (04) : 613 - +
  • [30] Dissolution Specifications for Ibuprofen Soft Gelatin Capsules: A Proposal
    Mayet-Cruz, Lourdes
    Rodriguez, Juan Manuel
    Juarez-Lopez, Emily
    Jung-Cook, Helgi
    DISSOLUTION TECHNOLOGIES, 2023, 30 (02): : 74 - 77