Reciprocal repression between P53 and TCTP

被引：0

作者：

Robert Amson

Salvatore Pece

Alexandra Lespagnol

Rajesh Vyas

Giovanni Mazzarol

Daniela Tosoni

Ivan Colaluca

Giuseppe Viale

Sylvie Rodrigues-Ferreira

Jessika Wynendaele

Olivier Chaloin

Johan Hoebeke

Jean-Christophe Marine

Pier Paolo Di Fiore

Adam Telerman

机构：

[1] Centre National de la Recherche Scientifique (CNRS)–Unité Mixte de Recherche (UMR) 8113,Dipartimento di Medicina

[2] Laboratoire de Biotechnologie et Pharmacologie génétique Appliquée (LBPA),undefined

[3] École Normale Supérieure,undefined

[4] Istituto Fondazione Italiana per la Ricerca sul Cancro (FIRC) di Oncologia Molecolare,undefined

[5] Istituto Europeo di Oncologia,undefined

[6] Chirurgia ed Odontoiatria,undefined

[7] University of Milan,undefined

[8] VIB - Katholieke Universiteit Leuven (KULeuven),undefined

[9] Campus Gasthuisberg,undefined

[10] Center for Biology of Disease,undefined

[11] Laboratory for Molecular Cancer Biology,undefined

[12] Institut de Biologie Moléculaire et Cellulaire,undefined

[13] Unité Propre (UPR) CNRS 9021,undefined

来源：

Nature Medicine | 2012年 / 18卷

关键词：

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中图分类号：

学科分类号：

摘要：

The authors find a reciprocal negative regulation loop between TCTP and P53. TCTP modulates P53 by competing with NUMB for MDM2 binding and increasing MDM2-mediated degradation of P53. This is reciprocated by p53's direct transcriptional repression of TCTP. Some human breast tumors have increased amounts of TCTP, which only in some cases correlateswith decreased P53 activity, and elevated TCTP is associated with poor prognosis and may influence P53-regulated stemness of tumor cells.

引用

页码：91 / 99

页数：8

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