The biological function of m6A demethylase ALKBH5 and its role in human disease

被引：0
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作者：
Jinyan Wang
Jinqiu Wang
Quan Gu
Yajun Ma
Yan Yang
Jing Zhu
Quan’an Zhang
机构：
[1] The Affiliated Jiangning Hospital of Nanjing Medical University,Department of Oncology, Nanjing Jiangning Hospital
[2] The Affiliated Jiangning Hospital of Jiangsu Health Vocational College,Department of Oncology
[3] Dafeng People’s Hospital,Department of Oncology
[4] The Affiliated Cancer Hospital of Nanjing Medical University,Department of Oncology
来源：
Cancer Cell International | / 20卷
关键词：
ALKBH5; m6A; Cancer; Non-cancer; Mechanisms; Prognosis;
D O I：
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摘要：
Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers through regulating kinds of biological processes, such as proliferation, migration, invasion, metastasis and tumor growth. In addition, it takes a great part in human non-cancer, including reproductive system diseases. The underlying regulatory mechanisms of ALKBH5 that relys on m6A-dependent modification are implicated with long non-coding RNA, cancer stem cell, autophagy and hypoxia. ALKBH5 is also an independent prognostic indicator in various cancers. In this review, we summarized the current evidence on ALKBH5 in diverse human cancers or non-cancers and its potential as a prognostic target.
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