Technology Development for the Synthesis of S-Amlodipine Nicotinate Drug Substance

被引：0

作者：

G. A. Kim

Zh. M. Kozlova

S. O. Pchelintsev

R. T. Savel’yanova

N. M. Berezina

I. I. Krasnyuk

机构：

[1] Ministry of Public Health of the Russian Federation,All

[2] I. M. Sechenov First Moscow State Medical University,Russia Scientific Center for Safety Testing of Biologically Active Substances

[3] EcoChem-Innovations,undefined

来源：

Pharmaceutical Chemistry Journal | 2017年 / 50卷

关键词：

-amlodipine nicotinate; amlodipine optical isomers; nicotinic acid;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Technology for the synthesis of S-amlodipine nicotinate drug substance was developed based on an acceptable method of effective separation of the amlodipine optical isomers. A literature review suggested that the most promising methods employed 2-propanol (pure or with small additions of cosolvents) as the main solvent. However, experiments showed that the optimum solvent was DMSO. The proposed synthesis of S-amlodipine nicotinate drug substance was confirmed to be stable and reproducible. Standardization methods were developed.

引用

页码：761 / 763

页数：2

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