The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution

被引：0

作者：

A. V. Fokin

P. V. Afonin

I. Yu. Mikhailova

I. N. Tsygannik

T. Yu. Mareeva

V. A. Nesmeyanov

W. Pangborn

N. Lee

W. Duax

E. Ciszak

V. Z. Pletnev

机构：

[1] Russian Academy of Sciences,Shemyakin

[2] Hauptman-Woodward Medical Research Center,Ovchinnikov Institute of Bioorganic Chemistry

[3] NASA,undefined

[4] Marshal Space Flight Center,undefined

来源：

Russian Journal of Bioorganic Chemistry | 2000年 / 26卷 / 9期

关键词：

monoclonal antibody, antigen-binding fragment, interleukin-2, X-ray analysis;

D O I：

10.1007/BF02758622

中图分类号：

学科分类号：

摘要：

The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 Å resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.

引用

页码：512 / 519

页数：7

共 13 条

[1] The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution
Fokin, AV
Afonin, PV
Mikhailova, IY
Tsygannik, IN
Mareeva, TY
Nesmeyanov, VA
Pangborn, W
Lee, N
Duax, W
Ciszak, E
Pletnev, VZ
[J]. BIOORGANICHESKAYA KHIMIYA, 2000, 26 (08): : 571 - 578
[2] A New Crystal Form of the Fab Fragment of a Monoclonal Antibody to Human Interleukin-2: The Three-Dimensional Structure at 2.7 Å Resolution
V. Z. Pletnev
E. A. Goryacheva
I. N. Tsygannik
V. A. Nesmeyanov
S. V. Pletnev
W. Pangborn
W. Daux
[J]. Russian Journal of Bioorganic Chemistry, 2004, 30 : 417 - 420
[3] A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2:: The three-dimensional structure at 2.7 Å resolution
Pletnev, VZ
Goryacheva, EA
Tsygannik, IN
Nesmeyanov, VA
Pletnev, SV
Pangborn, W
Daux, W
[J]. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2004, 30 (05) : 417 - 420
[4] CRYSTAL-STRUCTURE OF THE ANTIGEN-BINDING FRAGMENT OF THE MURINE ANTI-ARSONATE MONOCLONAL-ANTIBODY 36-71 AT 2.9-A RESOLUTION
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[5] Three-Dimensional Structure of Fab Fragment of Monoclonal Antibody LNKB-2 Complexed with Antigenic Nonaptide from Human Interleukin-2
E. A. Goryacheva
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N. V. Pletneva
V. Z. Pletnev
[J]. Russian Journal of Bioorganic Chemistry, 2023, 49 : 81 - 85
[6] Three-Dimensional Structure of Fab Fragment of Monoclonal Antibody LNKB-2 Complexed with Antigenic Nonaptide from Human Interleukin-2
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[J]. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2023, 49 (01) : 81 - 85
[7] Crystal structure of the antigen-binding fragment of apoptosis inducing mouse anti-human Fas monoclonal antibody HFE7A
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[8] Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein
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[J]. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2016, 72 : 636 - 641
[9] Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody
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[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (01) : 133 - 142
[10] High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes
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