A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2:: The three-dimensional structure at 2.7 Å resolution

被引：1

作者：

Pletnev, VZ

Goryacheva, EA

Tsygannik, IN

Nesmeyanov, VA

Pletnev, SV

Pangborn, W

Daux, W

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[2] Russian Acad Sci, AV Shubnikov Crystallog Inst, Moscow 117333, Russia

[3] Hauptman Woodward Med Res Ctr, Buffalo, NY 14203 USA

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2004年 / 30卷 / 05期

关键词：

antigen-binding fragment; interkeukin-2; monoclonal antibodies; X-ray analysis;

D O I：

10.1023/B:RUBI.0000043783.73562.ef

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in a new crystal form (space group P2(1)2(1)2(1); unit cell parameters: a=42.82 Angstrom, b=90.68 Angstrom and c=139.82 Angstrom) was determined by the X-ray molecular replacement method at the resolution of 2.7 Angstrom. The protein folding and the stereochemistry of its antigen-binding site were comparatively analyzed.

引用

页码：417 / 420

页数：4

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