Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation

被引:0
|
作者
Chu-Xia Deng
Frank Scott
机构
[1] Genetics of Development and Disease Branch,
[2] 10/9N105,undefined
[3] National Institute of Diabetes,undefined
[4] Digestive and Kidney Diseases,undefined
[5] National Institutes of Health,undefined
来源
Oncogene | 2000年 / 19卷
关键词
Brca1; p53; centrosome; G; -M checkpoint; tumorigenesis;
D O I
暂无
中图分类号
学科分类号
摘要
Germline mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers. Current evidence demonstrates that mutations in BRCA1 do not directly result in tumor formation, but instead cause genetic instability, subjecting cells to high risks of malignant transformation. In an animal model in which Brca1 is mutated specifically in mammary epithelium, tumorigenesis occurs in mutant glands at low frequency after a long latency. Notably, introduction of a p53-null allele significantly enhanced mammary gland tumor formation in Brca1 conditional mutant mice. These results are consistent with a model that Brca1 is a caretaker gene, whose absence causes genetic instability and triggers further alterations, including inactivation of tumor suppressor genes and/or activation of oncogenes, leading to tumor formation.
引用
收藏
页码:1059 / 1064
页数:5
相关论文
共 50 条
  • [11] Induction of apoptosis by the tumor suppressor protein BRCA1
    Shao, NS
    Chai, YL
    Shyam, E
    Reddy, P
    Rao, NV
    ONCOGENE, 1996, 13 (01) : 1 - 7
  • [12] The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
    Hakem, R
    delaPompa, JL
    Sirard, C
    Mo, R
    Woo, M
    Hakem, A
    Wakeham, A
    Potter, J
    Reitmair, A
    Billia, F
    Firpo, E
    Hui, CC
    Roberts, J
    Rossant, J
    Mak, TW
    CELL, 1996, 85 (07) : 1009 - 1023
  • [13] Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1
    Seo, Aaron
    Steinberg-Shemer, Orna
    Unal, Sule
    Casadei, Silvia
    Walsh, Tom
    Gumruk, Fatma
    Shalev, Stavit
    Shimamura, Akiko
    Akarsu, Nurten Ayse
    Tamary, Hannah
    King, Mary-Claire
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (20) : 5241 - 5246
  • [14] Differential gene expression in cells with targeted deletion of BRCA1 tumor suppressor
    Olga Aprelikova
    Amy Pace
    Beverly Koller
    Edison Liu
    Nature Genetics, 2001, 27 (Suppl 4) : 39 - 39
  • [15] Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice
    Bachelier, R
    Xu, XL
    Li, CL
    Qiao, WH
    Furth, PA
    Lubet, RA
    Deng, CX
    ONCOLOGY REPORTS, 2005, 14 (05) : 1117 - 1120
  • [16] MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene
    Molli, P. R.
    Singh, R. R.
    Lee, S. W.
    Kumar, R.
    ONCOGENE, 2008, 27 (14) : 1971 - 1980
  • [17] MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene
    P R Molli
    R R Singh
    S W Lee
    R Kumar
    Oncogene, 2008, 27 : 1971 - 1980
  • [18] BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis
    Li, Qianyan
    Engebrecht, JoAnne
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [19] TUSC4 functions as tumor suppressor by regulating BRCA1 stability and functions
    Peng, Yang
    Lin, Shiaw-Yih
    CANCER RESEARCH, 2014, 74 (19)
  • [20] Evaluation of promoter hypermethylation of tumor suppressor gene BRCA1 in epithelial ovarian cancer
    Das, Jhuma
    Chandra, Lal
    Gandhi, Gauri
    Amle, Dnyanesh B.
    Patnayak, Rachana L.
    Khurana, Nita
    Saxena, Alpana
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2022, 18 (06) : 1578 - 1582