RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

被引：0
|
作者：
Sarah K Deng
Bryan Gibb
Mariana Justino de Almeida
Eric C Greene
Lorraine S Symington
机构：
[1] Columbia University College of Physicians and Surgeons,Department of Microbiology and Immunology
[2] Columbia University College of Physicians and Surgeons,Department of Biochemistry and Biophysics
[3] Howard Hughes Medical Institute,undefined
[4] Columbia University College of Physicians and Surgeons,undefined
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
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摘要：
Resection of DNA double strand–break ends generates single strands that can spontaneously anneal to undergo mutagenic microhomology-mediated end joining (MMEJ). A combination of genetic and biophysical assays now shows that replication protein A (RPA) thwarts strand annealing by binding to the resected ends to promote Rad51 filament assembly and error-free repair by homologous recombination.
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页码：405 / 412
页数：7
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