RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

被引：0

作者：

Sarah K Deng

Bryan Gibb

Mariana Justino de Almeida

Eric C Greene

Lorraine S Symington

机构：

[1] Columbia University College of Physicians and Surgeons,Department of Microbiology and Immunology

[2] Columbia University College of Physicians and Surgeons,Department of Biochemistry and Biophysics

[3] Howard Hughes Medical Institute,undefined

[4] Columbia University College of Physicians and Surgeons,undefined

来源：

Nature Structural & Molecular Biology | 2014年 / 21卷

关键词：

D O I：

暂无

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学科分类号：

摘要：

Resection of DNA double strand–break ends generates single strands that can spontaneously anneal to undergo mutagenic microhomology-mediated end joining (MMEJ). A combination of genetic and biophysical assays now shows that replication protein A (RPA) thwarts strand annealing by binding to the resected ends to promote Rad51 filament assembly and error-free repair by homologous recombination.

引用

页码：405 / 412

页数：7

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