Phase II study of Temodal in the treatment of patients with advanced nasopharyngeal carcinoma

被引：0
|
作者：
Anthony T. C. Chan
Thomas W. T. Leung
Wing H. Kwan
Tony S. K. Mok
Winnie Yeo
Maria Lai
Philip J. Johnson
机构：
[1] Department of Clinical Oncology,
[2] Chinese University of Hong Kong,undefined
[3] Prince of Wales Hospital,undefined
[4] Shatin,undefined
[5] Hong Kong,undefined
[6] China Tel.: (852) 2632 2144; Fax: (852) 2649 7426; e-mail: anthonytcchan@cuhk.edu.hk,undefined
来源：
Cancer Chemotherapy and Pharmacology | 1998年 / 42卷
关键词：
Key words Nasopharyngeal carcinoma; Temodal;
D O I：
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学科分类号：
摘要：
Purpose: A single-institution phase II trial of Temodal (temozolomide, SCH52365) in Chinese patients with advance nasopharyngeal carcinoma was undertaken to determine the efficacy and safety of the drug in this population. Methods: A total of 14 patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma were entered into the study. One patient was unevaluable. Temodal was given at doses of 150 or 200 mg/m2 daily on days 1–5 every 28 days. Results: In all, 30 cycles of Temodal were given with no significant toxicity. All 13 (100%) evaluable patients had progressive disease after 2 (84.6%) or 4 (15.4%) courses. Conclusion: Temodal given on this schedule has no activity in advanced nasopharyngeal carcinoma.
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页码：247 / 249
页数：2
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