Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma
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作者:
Chua, Daniel T. T.
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Univ Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
Chua, Daniel T. T.
[1
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Wei, William I.
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Univ Hong Kong, Queen Mary Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
Wei, William I.
[2
]
Wong, Maria P.
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Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
Wong, Maria P.
[3
]
Sham, Jonathan S. T.
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Univ Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
Sham, Jonathan S. T.
[1
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Nicholls, John
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Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
Nicholls, John
[3
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Au, Gordon K. H.
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Univ Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
Au, Gordon K. H.
[1
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机构:
[1] Univ Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Queen Mary Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
Background. This single-center, phase II study assessed the safety/tolerability and initial efficacy of gefitinib in patients with nasopharyngeal carcinoma (NPC) pretreated with platinum-based chemotherapy. Methods. Patients with recurrent and metastatic NPC who had treatment failure with at least 2 lines of chemotherapy including platinum were given gefitinib at a fixed dose of 250 mg daily. Treatment was continued until the patient experienced unacceptable side effects or disease progression. Results, Nineteen patients were enrolled, having had treatment failure with a median of 2 chemotherapy regimens. Treatment was well tolerated, and only grades 1 to 2 adverse events were observed. None of the patients achieved partial or complete response, Median time-to-progression was 4 months, and median overall survival was 16 months. Conclusion. Gefitinib was well tolerated, but the response rate was poor in this heavily pretreated study population, and its use in NPC is not recommended outside the context of clinical trial. (c) 2008 Wiley Periodicals, Inc.
机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Hui, Edwin Pun
Ma, Brigette
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Ma, Brigette
Mo, Frankie
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Mo, Frankie
Kam, Michael K. M.
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Kam, Michael K. M.
Chan, Stephen Lam
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Chan, Stephen Lam
Loong, Herbert H. F.
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Loong, Herbert H. F.
Ho, Rosalie
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Ho, Rosalie
Leung, Sing Fai
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Leung, Sing Fai
King, Ann Dorothy
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
King, Ann Dorothy
Wang, Ki
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Wang, Ki
Ahuja, Anil Tejbhan
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Ahuja, Anil Tejbhan
Chan, Charles
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Chan, Charles
Hui, Connie W. C.
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Hui, Connie W. C.
Wong, Chi Hang
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
Wong, Chi Hang
Chan, Anthony T. C.
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机构:Chinese Univ Hong Kong, Partner State Key Lab Oncol South China, Sir YK Pao Ctr Canc, Dept Clin Oncol,Hong Kong Canc Inst, Shatin, Hong Kong, Peoples R China
机构:
Guilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Mo, Yunyan
Pan, Yufei
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Nanxishan Hosp Guangxi Zhuang Autonomous Reg, Dept Radiat Oncol, Guilin 541004, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Pan, Yufei
Zhang, Bin
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Wuzhou Red Cross Hosp, Dept Radiat Oncol, Wuzhou, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Zhang, Bin
Zhang, Jian
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Laibin Peoples Hosp, Dept Radiat Oncol, Laibin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Zhang, Jian
Su, Yixin
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Lingshan Cty Peoples Hosp, Dept Radiat Oncol, Qinzhou, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Su, Yixin
Liu, Zhengchun
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Liu, Zhengchun
Luo, Meiqing
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Guilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Luo, Meiqing
Qin, Guanjie
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Qin, Guanjie
Kong, Xiangyun
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Kong, Xiangyun
Zhang, Rongjun
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Zhang, Rongjun
Pan, Yu
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Pan, Yu
Liang, Yi
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Liang, Yi
Wang, Defeng
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Wang, Defeng
Wei, Yuejia
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Wei, Yuejia
Chen, Hengwei
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
Chen, Hengwei
Jiang, Wei
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Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
Guilin Med Univ, Educ Dept Guangxi Zhuang Autonomous Reg, Key Lab Oncol, Guilin, Peoples R ChinaGuilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China
机构:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China
Chan, ATC
Hsu, MM
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机构:Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China
Hsu, MM
Goh, BC
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Goh, BC
Hui, EP
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Hui, EP
Liu, TW
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机构:Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China
Liu, TW
Millward, MJ
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Millward, MJ
Hong, RL
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Hong, RL
Whang-Peng, J
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Whang-Peng, J
Ma, BBY
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Ma, BBY
To, KF
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机构:Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China
To, KF
Mueser, M
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机构:Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China
Mueser, M
Amellal, N
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机构:Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China
Amellal, N
Lin, X
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机构:Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China
Lin, X
Chang, AY
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机构:Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Oncol, Canc Therapeut Res Grp, Shatin, Hong Kong, Peoples R China