The role of NF-κB in 6-hydroxydopamine- and TNFα-induced apoptosis of PC12 cells

被引：0

作者：

Victoria Tarabin

Markus Schwaninger

机构：

[1] University of Heidelberg,Department of Neurology

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2004年 / 369卷

关键词：

6-Hydroxydopamine; NF-κB; Gene transcription; Neurodegeneration; Parkinson’s disease; TNFα;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

6-Hydroxydopamine (6-OHDA) is widely used to study the death of catecholaminergic cells related to Parkinson’s disease. Oxidative stress and gene transcription are known to mediate the pro-apoptotic effect of 6-OHDA. As redox mechanisms are involved in activation of the transcription factor NF-κB, we studied the role of NF-κB in 6-OHDA-induced death of PC12 cells.

引用

页码：563 / 569

页数：6

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