Genomic architecture of human neuroanatomical diversity

被引：0

作者：

R Toro

J-B Poline

G Huguet

E Loth

V Frouin

T Banaschewski

G J Barker

A Bokde

C Büchel

F M Carvalho

P Conrod

M Fauth-Bühler

H Flor

J Gallinat

H Garavan

P Gowland

A Heinz

B Ittermann

C Lawrence

H Lemaître

K Mann

F Nees

T Paus

Z Pausova

M Rietschel

T Robbins

M N Smolka

A Ströhle

G Schumann

T Bourgeron

机构：

[1] Human Genetics and Cognitive Functions,Neuroscience Department

[2] Institut Pasteur,Department of Child and Adolescent Psychiatry and Psychotherapy

[3] CNRS URA 2182 ‘Genes,Department of Psychiatry

[4] synapses and cognition’,Department of Addictive Behaviour and Addiction Medicine

[5] Université Paris Diderot,Department of Cognitive and Clinical Neuroscience

[6] Sorbonne Paris Cité,Department of Psychiatry and Psychotherapy

[7] Human Genetics and Cognitive Functions,Departments of Psychiatry and Psychology

[8] Henry H. Wheeler,Department of Adolescent Psychopathology and Medicine

[9] Jr. Brain Imaging Center,Psychology and Psychiatry Department

[10] University of California at Berkeley,Department of Psychiatry

[11] Berkeley,Department of Genetic Epidemiology in Psychiatry

[12] CA,Department of Psychology and Behavioural and Clinical Neuroscience Institute

[13] USA,Department of Psychiatry and Psychotherapy

[14] Neurospin,Department of Psychology

[15] Commissariat à l'Énergie Atomique et aux Énergies Alternatives,undefined

[16] Social,undefined

[17] Genetic and Developmental Psychiatry (SGDP) Centre,undefined

[18] Institute of Psychiatry,undefined

[19] King’s College London,undefined

[20] MRC Social,undefined

[21] Genetic and Developmental Psychiatry Centre,undefined

[22] Institute of Psychiatry,undefined

[23] Central Institute of Mental Health,undefined

[24] Medical Faculty Mannheim,undefined

[25] Heidelberg University,undefined

[26] Discipline of Psychiatry,undefined

[27] School of Medicine and Trinity College Institute of Neurosciences,undefined

[28] Trinity College Dublin,undefined

[29] University Medical Centre Hamburg-Eppendorf,undefined

[30] Université de Montreal,undefined

[31] CHU Ste Justine Hospital,undefined

[32] Montreal,undefined

[33] QC,undefined

[34] Canada,undefined

[35] Central Institute of Mental Health,undefined

[36] Medical Faculty Mannheim,undefined

[37] Heidelberg University,undefined

[38] Central Institute of Mental Health,undefined

[39] Medical Faculty Mannheim,undefined

[40] Heidelberg University,undefined

[41] Campus Charité Mitte,undefined

[42] Charité–Universitätsmedizin Berlin,undefined

[43] University of Vermont,undefined

[44] Physikalisch-Technische Bundesanstalt,undefined

[45] School of Psychology,undefined

[46] University of Nottingham,undefined

[47] Nottingham,undefined

[48] UK,undefined

[49] Institut National de la Santé et de la Recherche Medicale,undefined

[50] INSERM CEA Unit 1000,undefined

来源：

Molecular Psychiatry | 2015年 / 20卷

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摘要：

Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.

引用

页码：1011 / 1016

页数：5

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