Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations

被引：0

作者：

Julius Gudmundsson

Patrick Sulem

Daniel F Gudbjartsson

Jon G Jonasson

Asgeir Sigurdsson

Jon T Bergthorsson

Huiling He

Thorarinn Blondal

Frank Geller

Margret Jakobsdottir

Droplaug N Magnusdottir

Sigurborg Matthiasdottir

Simon N Stacey

Oskar B Skarphedinsson

Hafdis Helgadottir

Wei Li

Rebecca Nagy

Esperanza Aguillo

Eduardo Faure

Enrique Prats

Berta Saez

Mariano Martinez

Gudmundur I Eyjolfsson

Unnur S Bjornsdottir

Hilma Holm

Kristleifur Kristjansson

Michael L Frigge

Hoskuldur Kristvinsson

Jeffrey R Gulcher

Thorvaldur Jonsson

Thorunn Rafnar

Hannes Hjartarsson

Jose I Mayordomo

Albert de la Chapelle

Jon Hrafnkelsson

Unnur Thorsteinsdottir

Augustine Kong

Kari Stefansson

机构：

[1] deCODE genetics,Department of Pathology

[2] Sturlugata 8,Division of Endocrinology

[3] Landspitali-University Hospital Hringbraut,Division of Nuclear Medicine

[4] Faculty of Medicine,Division of Surgery

[5] University of Iceland,Department of Internal Medicine, Division of Cardiology

[6] The Icelandic Cancer Registry,Department of Surgery

[7] Human Cancer Genetics Program,H&N Surgery Department

[8] Comprehensive Cancer Center,Division of Medical Oncology

[9] The Ohio State University,Department of Oncology

[10] University Hospital,undefined

[11] University Hospital,undefined

[12] The Health Science Institute,undefined

[13] Nanotechnology Institute of Aragon,undefined

[14] University Hospital,undefined

[15] The Laboratory in Mjodd,undefined

[16] Emory University School of Medicine,undefined

[17] Landspitali-University Hospital Hringbraut,undefined

[18] ORL,undefined

[19] Landspitali-University Hospital Fossvogi,undefined

[20] Lozano Blesa University Hospital,undefined

[21] University of Zaragoza,undefined

[22] Landspitali-University Hospital Hringbraut,undefined

来源：

Nature Genetics | 2009年 / 41卷

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学科分类号：

摘要：

Julius Gudmundsson and colleagues report the association of two SNPs on chromosomes 9 and 14 with thyroid cancer in European populations. The variants are near FOXE1 and NKX2-1, both good biological candidates, and individuals who are homozygous for both risk variants have a 5.7-fold greater risk of thyroid cancer.

引用

页码：460 / 464

页数：4

共 35 条

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