Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations

被引:0
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作者
Julius Gudmundsson
Patrick Sulem
Daniel F Gudbjartsson
Jon G Jonasson
Asgeir Sigurdsson
Jon T Bergthorsson
Huiling He
Thorarinn Blondal
Frank Geller
Margret Jakobsdottir
Droplaug N Magnusdottir
Sigurborg Matthiasdottir
Simon N Stacey
Oskar B Skarphedinsson
Hafdis Helgadottir
Wei Li
Rebecca Nagy
Esperanza Aguillo
Eduardo Faure
Enrique Prats
Berta Saez
Mariano Martinez
Gudmundur I Eyjolfsson
Unnur S Bjornsdottir
Hilma Holm
Kristleifur Kristjansson
Michael L Frigge
Hoskuldur Kristvinsson
Jeffrey R Gulcher
Thorvaldur Jonsson
Thorunn Rafnar
Hannes Hjartarsson
Jose I Mayordomo
Albert de la Chapelle
Jon Hrafnkelsson
Unnur Thorsteinsdottir
Augustine Kong
Kari Stefansson
机构
[1] deCODE genetics,Department of Pathology
[2] Sturlugata 8,Division of Endocrinology
[3] Landspitali-University Hospital Hringbraut,Division of Nuclear Medicine
[4] Faculty of Medicine,Division of Surgery
[5] University of Iceland,Department of Internal Medicine, Division of Cardiology
[6] The Icelandic Cancer Registry,Department of Surgery
[7] Human Cancer Genetics Program,H&N Surgery Department
[8] Comprehensive Cancer Center,Division of Medical Oncology
[9] The Ohio State University,Department of Oncology
[10] University Hospital,undefined
[11] University Hospital,undefined
[12] The Health Science Institute,undefined
[13] Nanotechnology Institute of Aragon,undefined
[14] University Hospital,undefined
[15] The Laboratory in Mjodd,undefined
[16] Emory University School of Medicine,undefined
[17] Landspitali-University Hospital Hringbraut,undefined
[18] ORL,undefined
[19] Landspitali-University Hospital Fossvogi,undefined
[20] Lozano Blesa University Hospital,undefined
[21] University of Zaragoza,undefined
[22] Landspitali-University Hospital Hringbraut,undefined
来源
Nature Genetics | 2009年 / 41卷
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摘要
Julius Gudmundsson and colleagues report the association of two SNPs on chromosomes 9 and 14 with thyroid cancer in European populations. The variants are near FOXE1 and NKX2-1, both good biological candidates, and individuals who are homozygous for both risk variants have a 5.7-fold greater risk of thyroid cancer.
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页码:460 / 464
页数:4
相关论文
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