MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome

被引：0
|
作者：
J C Hassel
A Sucker
L Edler
H Kurzen
I Moll
C Stresemann
K Spieth
C Mauch
K Rass
R Dummer
D Schadendorf
机构：
[1] Skin Cancer Unit,Department of Biostatistics
[2] German Cancer Research Center,Department of Epigenetics
[3] University Hospital Mannheim,Department of Dermatology
[4] German Cancer Research Center,Department of Dermatology
[5] German Cancer Research Center,Department of Dermatology
[6] Johann Wolfgang Goethe-University,Department of Dermatology
[7] University of Cologne,Department of Dermatology
[8] Saarland University Hospital,undefined
[9] University Hospital Zurich,undefined
[10] University Hospital Essen,undefined
[11] Hufelandstr. 55,undefined
[12] Bayer-Schering,undefined
[13] Müllerstr. 178,undefined
来源：
British Journal of Cancer | 2010年 / 103卷
关键词：
MGMT; gene methylation; melanoma; therapy toxicity; temozolomide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：820 / 826
页数：6
相关论文
共 50 条
  • [21] Survival outcomes associated with MGMT promoter methylation and temozolomide in gliosarcoma patients
    Vasileios K. Kavouridis
    Keith L. Ligon
    Patrick Y. Wen
    J. Bryan Iorgulescu
    Journal of Neuro-Oncology, 2022, 158 : 111 - 116
  • [22] MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma
    Tuominen, Rainer
    Jewell, Rosalyn
    van den Oord, Joost J.
    Wolter, Pascal
    Stierner, Ulrika
    Lindholm, Christer
    Johansson, Carolina Hertzman
    Linden, Diana
    Johansson, Hemming
    Stolt, Marianne Frostvik
    Walker, Christy
    Snowden, Helen
    Newton-Bishop, Julia
    Hansson, Johan
    Brage, Suzanne Egyhazi
    INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (12) : 2844 - 2853
  • [23] MGMT gene promoter methylation in pediatric glioblastomas
    Srivastava, Arti
    Jain, Ayushi
    Jha, Prerana
    Suri, Vaishali
    Sharma, Mehar Chand
    Mallick, Supriya
    Puri, Tarun
    Gupta, Deepak Kumar
    Gupta, Aditya
    Sarkar, Chitra
    CHILDS NERVOUS SYSTEM, 2010, 26 (11) : 1613 - 1618
  • [24] METHYLATION STATUS OF MGMT GENE PROMOTER IN MENINGIOMAS
    De Robles, Paula
    Mcintyre, J.
    Kalra, S.
    Roldan, Gloria
    Cairncross, Gregory
    Forsyth, Peter
    Magliocco, Tony
    Hamilton, Mark
    Easaw, Jacob
    NEURO-ONCOLOGY, 2008, 10 (05) : 860 - 860
  • [25] Methylation status of MGMT gene promoter in meningiomas
    de Robles, Paula
    McIntyre, John
    Kalra, Sanjog
    Roldan, Gloria
    Cairncross, Gregory
    Forsyth, Peter
    Magliocco, Tony
    Hamilton, Mark
    Easaw, Jacob
    CANCER GENETICS AND CYTOGENETICS, 2008, 187 (01) : 25 - 27
  • [26] MGMT gene promoter methylation in pediatric glioblastomas
    Arti Srivastava
    Ayushi Jain
    Prerana Jha
    Vaishali Suri
    Mehar Chand Sharma
    Supriya Mallick
    Tarun Puri
    Deepak Kumar Gupta
    Aditya Gupta
    Chitra Sarkar
    Child's Nervous System, 2010, 26 : 1613 - 1618
  • [27] MGMT promoter methylation determined by the MGMT-STP27 algorithm is not predictive for outcome to temozolomide in IDH-mutant anaplastic astrocytomas
    Tesileanu, C. Mircea S.
    Gorlia, Thierry
    Golfinopoulos, Vassilis
    French, Pim J.
    van den Bent, Martin J.
    NEURO-ONCOLOGY, 2022, 24 (04) : 665 - 667
  • [28] Clinical value of the MGMT promoter methylation score in IDHmt low-grade glioma for predicting benefit from temozolomide treatment
    Darlix, Amelie
    Bady, Pierre
    Deverdun, Jeremy
    Lefort, Karine
    Rigau, Valerie
    Le Bars, Emmanuelle
    Meriadec, Justine
    Carriere, Mathilde
    Coget, Arthur
    Santarius, Thomas
    Matys, Tomasz
    Duffau, Hugues
    Hegi, Monika E.
    NEURO-ONCOLOGY ADVANCES, 2025, 7 (01)
  • [29] Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation
    Pietrantonio, F.
    Perrone, F.
    de Braud, F.
    Castano, A.
    Maggi, C.
    Bossi, I.
    Gevorgyan, A.
    Biondani, P.
    Pacifici, M.
    Busico, A.
    Gariboldi, M.
    Festinese, F.
    Tamborini, E.
    Di Bartolomeo, M.
    ANNALS OF ONCOLOGY, 2014, 25 (02) : 404 - 408
  • [30] Frequent MGMT gene promoter methylation in brain metastases of melanoma, lung, breast and renal carcinoma
    Ingold, B.
    Schraml, P.
    Stopatschinskaja, S.
    Heppner, F. L.
    Moch, H.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
12345