Peptidergic Regulation of Thymocyte Differentiation, Proliferation, and Apoptosis during Aging of the Thymus

被引:0
|
作者
N. S. Lin’kova
V. O. Polyakova
A. V. Trofimov
I. M. Kvetnoy
V. Kh. Khavinson
机构
[1] North Western Division of the Russian Academy of Medical Sciences,St. Petersburg Institute of Bioregulation and Gerontology
关键词
geroprotective peptides; proliferation; apoptosis; differentiation; thymocytes;
D O I
暂无
中图分类号
学科分类号
摘要
The effects of T-31, AB-17, and AB-9 peptides on old (passage 8) thymocyte culture were studied. Only AB-9 peptide exhibited a complex geroprotective effect on thymocytes during their aging. Peptide AB-9 stimulated proliferative activity and differentiation of thymocytes and inhibited their apoptosis.
引用
收藏
页码:239 / 242
页数:3
相关论文
共 50 条
  • [21] Cell cycle regulation in the lens: Proliferation, quiescence, apoptosis and differentiation
    Zelenka, PS
    Gao, CY
    Rampalli, A
    Arora, J
    Chauthaiwale, V
    He, HY
    PROGRESS IN RETINAL AND EYE RESEARCH, 1997, 16 (02) : 303 - 322
  • [22] Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
    Abdeljabar El Andaloussi
    Stephanie Graves
    Fanyong Meng
    Malay Mandal
    Mona Mashayekhi
    Iannis Aifantis
    Nature Immunology, 2006, 7 : 418 - 426
  • [23] Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
    El Abdaloussi, E
    Graves, S
    Meng, FY
    Mandal, M
    Mashayekhi, M
    Aifantis, I
    NATURE IMMUNOLOGY, 2006, 7 (04) : 418 - 426
  • [24] INVIVO PROLIFERATION AND DIFFERENTIATION OF PROTHYMOCYTES IN THE THYMUS
    PENIT, C
    IMMUNOLOGIC RESEARCH, 1987, 6 (04) : 271 - 278
  • [25] IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection
    Boudil, Amine
    Matei, Irina R.
    Shih, Han-Yu
    Bogdanoski, Goce
    Yuan, Julie S.
    Chang, Stephen G.
    Montpellier, Bertrand
    Kowalski, Paul E.
    Voisin, Veronique
    Bashir, Shaheena
    Bader, Gary D.
    Krangel, Michael S.
    Guidos, Cynthia J.
    NATURE IMMUNOLOGY, 2015, 16 (04) : 397 - 405
  • [26] IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection
    Amine Boudil
    Irina R Matei
    Han-Yu Shih
    Goce Bogdanoski
    Julie S Yuan
    Stephen G Chang
    Bertrand Montpellier
    Paul E Kowalski
    Veronique Voisin
    Shaheena Bashir
    Gary D Bader
    Michael S Krangel
    Cynthia J Guidos
    Nature Immunology, 2015, 16 : 397 - 405
  • [27] ALVEOLAR MACROPHAGE REGULATION OF RABBIT THYMOCYTE PROLIFERATION
    PULIDO, M
    GALINDO, B
    JOURNAL OF THE RETICULOENDOTHELIAL SOCIETY, 1978, 24 (DEC): : A52 - A52
  • [28] Alterations in the Peptidergic Regulation of Energy Balance in the Course of Aging
    Petervari, E.
    Soos, S.
    Szekely, M.
    Balasko, M.
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2011, 12 (04) : 316 - 324
  • [29] Effect of VEGF on mouse thymocyte proliferation and apoptosis in vitro
    Kiseleva, EP
    Krylov, AV
    Lyudyno, VI
    Suvorov, AN
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2005, 139 (05) : 576 - 579
  • [30] Effect of VEGF on Mouse Thymocyte Proliferation and Apoptosis In Vitro
    E. P. Kiseleva
    A. V. Krylov
    V. I. Lyudyno
    A. N. Suvorov
    Bulletin of Experimental Biology and Medicine, 2005, 139 : 576 - 579