Landscape of somatic mutations in aging human heart muscle cells

被引：0
|
作者：
机构：
来源：
Nature Aging | 2022年 / 2卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.
引用
收藏
页码：686 / 687
页数：1
相关论文
共 50 条
  • [41] SOMATIC MUTATIONS AND AGING - CAUSE OR EFFECT - PREFACE
    VIJG, J
    MUTATION RESEARCH-DNAGING GENETIC INSTABILITY AND AGING, 1995, 338 (1-6): : 1 - 2
  • [42] Interplay of somatic mutations and epigenetic aging clocks
    Wagner, Wolfgang
    NATURE AGING, 2025, : 536 - 538
  • [43] Transcriptional Noise and Somatic Mutations in the Aging Pancreas
    Swisa, Avital
    Kaestner, Klaus H.
    Dor, Yuval
    CELL METABOLISM, 2017, 26 (06) : 809 - 811
  • [44] Somatic mutations, genome mosaicism, cancer and aging
    Vijg, Jan
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2014, 26 : 141 - 149
  • [45] Somatic mutations in neurons during aging and neurodegeneration
    Verheijen, Bert M.
    Vermulst, Marc
    van Leeuwen, Fred W.
    ACTA NEUROPATHOLOGICA, 2018, 135 (06) : 811 - 826
  • [46] Human Muscle-Derived Stem Cells Prevent Cardiac Dysfunction in the Aging Dystrophic Heart
    Chen, William C. W.
    Lu, Aiping
    Yessenov, Talgat
    Gao, Xueqin
    Tobita, Kimimasa
    Saparov, Arman
    Huard, Johnny
    MOLECULAR THERAPY, 2014, 22 : S194 - S195
  • [47] Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability
    Bae, Taejeong
    Fasching, Liana
    Wang, Yifan
    Shin, Joo Heon
    Suvakov, Milovan
    Jang, Yeongjun
    Norton, Scott
    Dias, Caroline
    Mariani, Jessica
    Jourdon, Alexandre
    Wu, Feinan
    Panda, Arijit
    Pattni, Reenal
    Chahine, Yasmine
    Yeh, Rebecca
    Roberts, Rosalinda C.
    Huttner, Anita
    Kleinman, Joel E.
    Hyde, Thomas M.
    Straub, Richard E.
    Walsh, Christopher A.
    Network, Brain Somatic Mosaicism
    Urban, Alexander E.
    Leckman, James F.
    Weinberger, Daniel R.
    Vaccarino, Flora M.
    Abyzov, Alexej
    SCIENCE, 2022, 377 (6605) : 511 - +
  • [48] The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging
    Sanchez-Contreras, Monica
    Sweetwyne, Mariya T.
    Tsantilas, Kristine A.
    Whitson, Jeremy A.
    Campbell, Matthew D.
    Kohrn, Brenden F.
    Kim, Hyeon Jeong
    Hipp, Michael J.
    Fredrickson, Jeanne
    Nguyen, Megan M.
    Hurley, James B.
    Marcinek, David J.
    Rabinovitch, Peter S.
    Kennedy, Scott R.
    ELIFE, 2023, 12
  • [49] Somatic mutations are frequent and increase with age in human kidney epithelial cells
    Martin, GM
    Ogburn, CE
    Colgin, LM
    Gown, AM
    Edland, SD
    Monnat, RJ
    HUMAN MOLECULAR GENETICS, 1996, 5 (02) : 215 - 221
  • [50] A pan-cancer landscape of somatic mutations in non-unique regions of the human genome
    Tarabichi, Maxime
    Demeulemeester, Jonas
    Verfaillie, Annelien
    Flanagan, Adrienne M.
    Van Loo, Peter
    Konopka, Tomasz
    NATURE BIOTECHNOLOGY, 2021, 39 (12) : 1589 - +
12345